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Archivo del Autor: Belen De Leon

NASA just shut down the pioneering space telescope Spitzer – CNET

After almost 17 years of staring into space, NASA has said good night to Spitzer.
Source: CNET

'Weathering With You' Is an Environmental Power Fantasy

The new anime film, from the creators of Your Name, puts the power to stop climate change into individuals’ hands. That’s where the real make-believe lies.
Source: Wired

Super Bowl 2020: How to watch 49ers vs. Chiefs without cable — livestreams, start time and more – CNET

You can live stream Super Bowl LIV for free, no cable subscription required.
Source: CNET

Mammoth Biosciences aims to be Illumina for the gene editing generation

In 1998, the startup company Illumina launched a revolution in the life sciences industry by developing technology to slash the costs of identifying and mapping genetic material.

Now, a little over twenty years later, Mammoth Biosciences is hoping to do the same thing for gene editing tools.

The company, co-founded by Jennifer Doudna, who did some of the pioneering work to discover the gene editing enzyme known as CRISPR, has just raised $45 million as it looks to bring to market products that can not be used not only for disease detection, but are more precise editing tools for genetic material.

Rather than get bogged down in the patent dispute that raged over the provenance and ownership of applications for the original CRISPR enzyme — the Cas9 discovered by Doudna and developed for clinical applications at the Broad Institute — Mammoth has joined a number of startups in identifying new enzymes with a broader array of properties.

“From the very beginning of the company we’ve only worked with novel new enzymes to create these diagnostic products and the new novel diagnostic and editing,” says Trevor Martin, Mammoth Biosciences co-founder and chief executive.

Chiefly, the company is touting its Cas14 enzyme, which the company says opens up new possibilities for programmable biology thanks to its small size, diverse targeting ability and high fidelity — meaning that there are no unforeseen side effects to edits made using the enzyme (something that has arisen with Cas9 applications).

“There’s not one protein that’s going to be the best at everything,” says Martin. “For any particular product that you’re building, at Mammoth, we have the broadest toolbox.”

The Cas14 enzyme can be used to make gene edits in-vivo, meaning in live organisms, instead of ex-vivo, or outside of an organism. The in-vivo use-case could accelerate the time it takes to conduct experiments or develop treatments.

“Twenty years from now, when the umpteenth drug gets approved using Crispr and some nuclease named Cas132013, people are going to look back on this patent battle and think, ‘what a godawful waste of money,’” Jacob Sherkow a patent law scholar at New York Law School told Wired back in 2018.

Already, Horizon Discovery, a Cambridge, UK-based gene editing technology developer, is using the new tools developed by Mammoth Bioscience to create new CRISPR tools for Chinese Hamster Ovary cell line editing.

That partnership is an example of how Mammoth is thinking about the commercialization of the new Cas14 enzyme line and its role in biological engineering.

“You will need a full toolbox of CRISPR proteins,” says Martin. “That will allow you to interact with biology in the same way that wee interact with software and computers. “From first principles, companies will programmatically modify biology to cure a disease or decrease risk for a disease. That’s going to be really kind of a turning point.”

To achieve its vision, Mammoth has managed to nab top talent from the life sciences industry including, Peter Nell, a co-founder of Casebia (a joint venture between Bayer and CRISPR Therapeutics), who came on board as chief business officer, and Ted Tisch, a former executive at Synthego and Bio-Rad, joined the company as chief operating officer

The company also nabbed $45 million of funding including investment firms Mayfield, NFX, Verily (the Alphabet subsidiary), and Brook Byers, which was led by Decheng Capital — bringing the company to over $70 million in funding.

“There are a dozen or so products that are in clinical development with CRISPR,” says Ursheet Parikh, a partner with Mayfield. “Maybe that number would go up by five or ten without Mammoth, but it will go up by one or two orders of magnitude with Mammoth.”

To Parikh, Mammoth is the best positioned of the CRISPR development tools, because the company is building a whole platform that customers can license and use to develop products using gene editing.

The thinking, according to Parikh is as follows, “if this technology can power lots of applications, let’s basically ensure that lots of these applications can come to market and as that happens I get my app store cut.”

“It’s an Illumina-like business,” Parikh says. “Just as anybody who is innovating with genomics needs an illumina sequencer because they want to be able to do the sequencing… if someone wants to do editing… This gives them the access to do the right sequencing.”

 


Source: TechCrunch

2020 Dodge Durango SRT gets Black design package and Redline stripes – Roadshow

The two new accessory packages will be exclusive to the Durango SRT.
Source: CNET

GMC's electric Hummer packs 1,000 horsepower and a 3-second 0-60 time – Roadshow

The all-electric, reborn Hummer will battle Tesla’s Cybertruck when it launches in 2021.
Source: CNET

New Hummer EV will debut in Super Bowl ad with LeBron James – Roadshow

GMC is using the Super Bowl to introduce its new Hummer EV to the world, with a little help from LeBron James.
Source: CNET

Arvind Krishna will replace Ginni Rometty as IBM CEO in April

IBM announced today that the board of directors has elected IBM senior vice president for Cloud and Cognitive Software Arvind Krishna to replace current CEO Ginni Rometty. He will take over on April 6th after a couple of months of transition. Rometty will remain with the company as chairman of the board.

Krishna reportedly drove the massive $34 billion acquisition of Red Hat at the end of 2018, and there was some speculation at the time that Red Hat CEO Jim Whitehurst was the heir apparent, but the board went with a more seasoned IBM insider for the job, while naming Whitehurst as president.

In a statement Rometty called Krishna the right man for the job, as she steps back after more than eight years on the job. “Through his multiple experiences running businesses in IBM, Arvind has built an outstanding track record of bold transformations and proven business results, and is an authentic, values-driven leader. He is well-positioned to lead IBM and its clients into the cloud and cognitive era,” she said in a statement.

She added that in choosing Krishna and Whitehurst, the board chose a technically and business savvy team to lead the company moving forward. It’s clear that the board went with two men who have a deep understanding of cloud and cognitive computing technologies, two areas that are obviously going to be front and center of technology for the foreseeable future, and areas where IBM needs to thrive.

Ray Wang, founder and principal analyst at Constellation Research, sees the CEO-president model as a sound approach. “It’s and inside-outside model. To truly understand IBM, you have to come from the inside [like Krishna], but to truly innovate you need someone on the outside [like Whitehurst] and that CEO-president model is helping,” he said.

Patrick Moorhead, founder and principal analyst at Moor Insights & Strategies, says that he was surprised by the timing of the announcement, which seemed to come out of nowhere. “I am a bit surprised at the speed of this announcement as I don’t believe there was a formal succession plan with a named successor. IBM has always had these and it was always apparent who the next CEO would be,” he said. That was not the case this time.

But like Wang, Moorhead likes the approach of having an “outsider” and long-time IBMer working in tandem. “Krishna spearheaded many of the next-generation IBM initiatives like the Red Hat acquisition, blockchain and quantum. I am also very pleased to see Whitehurst appointed president as now there’s an outsider and a long-time IBMer running the company in the number one and two spots,” he said.

Wang believes the new leaders have to honestly assess the company’s strengths and weaknesses and find ways to compete with today’s cloud companies for the hearts and minds of the enterprise customers.

“Today IBM is in an interesting position where the world has changed, and people go to Amazon or Salesforce or they go to Google or Workday or Microsoft. Companies still have a lot of IBM, they still trust IBM, but the new leadership team needs to figure out where the technology gaps are, which ones they need to build, which ones they need to partner, and in some cases say, this is not our market,” he said.


Source: TechCrunch

SpaceX reportedly looking to build Starship rockets at Port of LA

SpaceX is said to be in talks with local government officials about setting up a new rocket factory in the Port of Los Angeles, a location that would give it easy access to the ocean for transporting its next-generation Starship and Super Heavy launch vehicles to its coastal launchpad sites in Florida. CNBC reported that these discussions were confirmed by Port of LA officials.

As CNBC points out, this isn’t the first time that SpaceX has done this dance with the Port of LA: The company had received approval to build a manufacturing facility in the port two years ago, and agreed on a 10-year, $1.4 million-per-year lease, before subsequently going back on that agreement in 2019.

Currently, SpaceX is building its Starship prototype for orbital testing at a facility in Boca Chica, Texas. That’s a one-off vehicle however, intended for the purpose of testing and working out the final design for the Starship, which is meant to be a fully reusable spacecraft, which in tandem with SpaceX’s forthcoming “Super Heavy” booster will be able to take large payloads to orbit — and ultimately to the Moon and Mars.

SpaceX CEO Elon Musk has shared eventual plans for Starship that involve flying them with very high frequency, and ultimately attaining a rate of construction of 100 Starships per year with the aim of producing 1,000 over the course of the next 10 years. Musk says that this rate of production is required to perform cargo and passenger flights with the frequency and volume needed to establish a permanent human presence on Mars — which, ultimately, has been his goal all along with SpaceX.

It stands to reason that building that many large vehicles in that span of time would require additional production facility resources. SpaceX currently manufactures Falcon 9 and Falcon Heavy at its facility in Hawthorne, Calif., and then transports those in sections over land, but Starship and Super Heavy will be considerably larger and will likely require transportation by water to reach SpaceX’s launch sites.

CNBC’s report cites LA City Councilman Joe Buscaino as saying that SpaceX might seek to be up and running with at least a temporary production facility in as little as 90 days, though no deal is yet finalized between the parties.


Source: TechCrunch

Being a child actress prepared me for a career in venture capital 

It takes guts to be a VC, but being a child actress prepared me well for the challenge.

In addition to the serial rejection even the most successful actors experience in audition after audition, life on set isn’t always a picnic. When I was on “The Wonder Years,” we filmed an episode called “The St. Valentine’s Day Massacre,” in which my character, Becky Slater, attempts to run over longtime foe Kevin Arnold with her bicycle.

During a dress rehearsal, as I sped up on the ancient, too-tall 1960’s-era bike, my front wheel hit a thick sound cable that hadn’t been there during a prior run-through; I went over the handlebars and spent the evening in the emergency room. A few days later, barely off crutches, I was back on set and back on the bike. We filmed the scene, and the episode was one of the series’ most successful and memorable. No one has ever accused me of timidity.

Many years later, armed with degrees from Yale and Harvard Law — plus years of experience advising companies as a lawyer and investing in them as a VC — I launched my own venture capital fund, Anathem Ventures. The grit and perseverance I first honed on studio soundstages serves me well, and these are also the qualities I look for in the founders I back.

Anathem Ventures CEO/founder Crystal McKellar


Source: TechCrunch

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